The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 12, 2026

Filed:

Nov. 11, 2019
Applicant:

Georgia Tech Research Corporation, Atlanta, GA (US);

Inventors:

Ali Fatih Sarioglu, Atlanta, GA (US);

Ningquan Wang, Atlanta, GA (US);

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
B01L 3/00 (2006.01); B29C 33/38 (2006.01); B29C 39/00 (2006.01); B29C 39/42 (2006.01); B29K 105/00 (2006.01); C23C 14/04 (2006.01); C23C 14/18 (2006.01); G01N 15/10 (2024.01); G01N 15/1404 (2024.01); G03F 7/00 (2006.01);
U.S. Cl.
CPC ...
B01L 3/502761 (2013.01); B01L 3/502707 (2013.01); B01L 3/502715 (2013.01); B01L 3/502776 (2013.01); B29C 33/3842 (2013.01); B29C 39/006 (2013.01); B29C 39/42 (2013.01); C23C 14/042 (2013.01); C23C 14/18 (2013.01); G01N 15/1023 (2024.01); G01N 15/1404 (2013.01); G03F 7/0017 (2013.01); B01L 2200/027 (2013.01); B01L 2200/0652 (2013.01); B01L 2200/12 (2013.01); B01L 2200/16 (2013.01); B01L 2300/0636 (2013.01); B01L 2300/0819 (2013.01); B01L 2300/0864 (2013.01); B01L 2300/12 (2013.01); B29K 2105/0002 (2013.01); G01N 2015/1019 (2024.01);
Abstract

A microfluidic device for particle analysis, such as immunophenotyping, includes a plurality of microfluidic channels for the passage of a particle-laden fluid flow, a plurality of dedicated impedance sensors for generating impedance signals relative to each microfluidic sensor. The impedance sensors are CODES Coulter sensors, each having a distinct coded sequence for generating mutually orthogonal signals. The system uses a multi-frequency excitation signal for driving the Coulter sensors, such that the Coulter sensors generate multi-frequency impedance signals. The system outputs the multi-frequency signals of the plurality of impedance sensors as a single multi-frequency multiplexed signal, which is subsequently separated into a plurality of single-frequency multiplexed signals, which are then demodulated into single-frequency component signals corresponding to each of the Coulter sensors.


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