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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12622931 B1

PDFFull Text
Date of Patent:
May. 12, 2026

Filed:

Feb. 13, 2020

Compositions and methods for treating alpha-1 antitrypsin deficiency

Applicant:

Beam Therapeutics Inc., Cambridge, MA (US);

Inventors:

Nicole Gaudelli, Cambridge, MA (US);

Michael Packer, Cambridge, MA (US);

Bernd Zetsche, Cambridge, MA (US);

Ian Slaymaker, Cambridge, MA (US);

Yi Yu, Cambridge, MA (US);

David A. Born, Cambridge, MA (US);

Seung-Joo Lee, Cambridge, MA (US);

Assignee:

BEAM THERAPEUTICS INC., Cambridge, MA (US);

Attorneys:

Greenberg Traurig, LLP

Melissa Hunter-Ensor

Nicholas R. Ballor

Primary Examiner:

Catherine Konopka

Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61K 31/7088 (2006.01); A61K 35/407 (2015.01); A61K 38/46 (2006.01); C12N 5/071 (2010.01); C12N 9/22 (2006.01); C12N 9/78 (2006.01); C12N 15/10 (2006.01); C12N 15/11 (2006.01);
U.S. Cl.
CPC ...
A61K 35/407 (2013.01); A61K 31/7088 (2013.01); A61K 38/465 (2013.01); A61K 48/0025 (2013.01); C12N 5/067 (2013.01); C12N 9/22 (2013.01); C12N 9/78 (2013.01); C12N 15/102 (2013.01); C12N 15/11 (2013.01); C12N 2310/20 (2017.05); C12N 2510/00 (2013.01);
Abstract

The present invention features compositions and methods for editing deleterious mutations associated with alpha-1 anti-trypsin (A1AT) deficiency. In particular embodiments, the invention provides methods for correcting mutations in an A1AT polynucleotide using an adenosine deaminase base editor. ABE8, having unprecedented levels of efficiency.

Find Patent Forward Citations

Gaudelli, Nicole. (2026). Compositions and methods for treating alpha-1 antitrypsin deficiency (U.S. Patent No. 12622931). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12622931

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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