The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 05, 2026
Filed:
Dec. 19, 2019
Paris Sciences ET Lettres, Paris, FR;
Centre National DE LA Recherche Scientifique, Paris, FR;
Institut Curie, Paris, FR;
The President and Fellows of Harvard College, Cambridge, MA (US);
Hifibio (Hk) Limited, Central Hong Kong, CN;
Ecole Superieure DE Physique ET DE Chimie Industrielles DE LA Ville DE Paris, Paris, FR;
Institut National DE LA Sante ET DE LA Recherche Medicale (Inserm), Paris, FR;
Andrew Griffiths, Paris, FR;
Sebastien Amigorena, Paris, FR;
Olivier Lantz, Paris, FR;
David Weitz, Bolton, MA (US);
Philippe Nghe, Saint-Mande, FR;
Annabelle Gerard, Palaiseau, FR;
PARIS SCIENCES ET LETTRES, Paris, FR;
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, Paris, FR;
INSTITUT CURIE, Paris, FR;
THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE, Cambridge, MA (US);
HIFIBIO (HK) LIMITED, Central Hong Kong, CN;
ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS, Paris, FR;
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), Paris, FR;
Abstract
A method for identifying cognate pairs of a ligand species and a receptor species includes co-compartmentalizing ligand species and receptor species, forming a set of microreactors, each microreactor including a ligand species and preferably a receptor species; assaying the recognition between ligands and receptors in each microreactor and based on this assay, classifying each microreactor as positive when a ligand species and receptor species in the microreactor recognize one with the other or negative when no ligand species and no receptor species recognize in the microreactor; identifying ligand species and receptor species contained in each positive microreactor; establishing a subset of positive microreactors containing the same receptor species; determining the probability that the ligand species recognizing the receptor species corresponds to the most frequent co-compartmentalized ligand species. If the determined probability exceeds a threshold, identifying as a cognate pair the receptor species and the most frequent co-compartmentalized ligand species.