The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 05, 2026
Filed:
Nov. 06, 2020
Applicant:
President and Fellows of Harvard College, Cambridge, MA (US);
Inventors:
Eric Kelsic, Cambridge, MA (US);
Sam Sinai, Somerville, MA (US);
Pierce Ogden, Somerville, MA (US);
George M. Church, Brookline, MA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 14/075 (2006.01); C12N 15/861 (2006.01);
U.S. Cl.
CPC ...
C07K 14/075 (2013.01); C12N 15/861 (2013.01); C12N 2750/14122 (2013.01); C12N 2750/14143 (2013.01);
Abstract
The technology described herein provides variant adeno-associated viral capsid polypeptides and viruses comprising the same. Such variant viral capsid polypeptides bear a mutation relative to SEQ ID NO: 2 (WT AAV2) in a region corresponding to amino acids 561-588, wherein the region corresponding to amino acids 561-588 comprises a sequence selected from SEQ ID NO: 4-41,337. Further provided herein are methods for delivering a viral payload using viruses comprising variant capsid polypeptides described herein.