Device and method for noninvasively and electrochemically sensing in vivo biochemicals

Abstract

Example implementations include a method of manufacturing a biochemical sensor by forming a fluid conduit in a microfluidic layer, forming an electrode on an electrode layer, forming a biochemical sensor on the electrode layer, bonding the electrode layer to a first surface of the microfluidic layer, and bonding a barrier layer to a second surface of the microfluidic layer. Example implementations also include a method of electrically detecting a biochemical by contacting an electrode array to a biological surface, obtaining a biofluid at the electrode array from the biological surface, obtaining a response current associated with the biofluid at the electrode array, and generating a quantitative biochemical response based at least partially on the response current. Example implementations further include applying a current to the biological surface. Example implementations further include filtering electrical interference at the electrode array. Example implementations further include generating a quantitative biochemical response based on the response current.