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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12616696 B1

PDFFull Text
Date of Patent:
May. 05, 2026

Filed:

Mar. 26, 2021

Crystalline forms of (p)-3-chloro-4-((3,5-difluoropyridin-2-yl)methoxy)-2'-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-5′,6-dimethyl-2h-[1,4′-bipyridin]-2-one

Applicant:

Aclaris Therapeutics, Inc., Wayne, PA (US);

Inventors:

Gary A. Decrescenzo, Parkville, MO (US);

John Robert Springer, Wentzville, MO (US);

Susan Landis Hockerman, Kirkwood, MO (US);

Assignee:

Aclaris Therapeutics, Inc., Wayne, PA (US);

Attorney:

DLA Piper LLP

Primary Examiner:

Douglas M Willis

Int. Cl.
CPC ...
A61K 31/506 (2006.01); A61K 9/00 (2006.01); A61K 9/20 (2006.01); A61K 45/06 (2006.01); A61P 11/00 (2006.01); A61P 31/14 (2006.01); A61P 37/06 (2006.01); C07D 239/24 (2006.01); C07D 401/14 (2006.01);
U.S. Cl.
CPC ...
A61K 31/506 (2013.01); A61K 9/0053 (2013.01); A61K 9/20 (2013.01); A61K 9/2009 (2013.01); A61K 9/2013 (2013.01); A61K 9/2018 (2013.01); A61K 9/2027 (2013.01); A61K 9/2054 (2013.01); A61K 45/06 (2013.01); A61P 11/00 (2018.01); A61P 31/14 (2018.01); A61P 37/06 (2018.01); C07D 401/14 (2013.01); C07B 2200/13 (2013.01);
Abstract

The present disclosure provides a crystalline form of the methyl/fluoro-pyridinyl-methoxy substituted pyridinone-pyridinyl compound of the structure: XRPD, TGA, and DSC data on the crystalline form, as well as methods preparing the crystalline form, including a multi-kilo scale preparation. Also provided are pharmaceutical compositions and methods of treating pmediated diseases, such as lymphoma and auto-inflammatory disease, including rheumatoid arthritis. and methods of maximizing the yield thereof comprising administering of the compound. Also provided is a method of maximizing the yield of said compound via a recycling procedure.

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