The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 28, 2026
Filed:
Jun. 26, 2020
Monash University, Clayton, AU;
Mogrify Limited, Cambridge, GB;
National University of Singapore, Singapore, SG;
Owen Rackham, Singapore, SG;
Enrico Petretto, Singapore, SG;
Uma Kamaraj, Singapore, SG;
Jose Polo, Clayton, AU;
Joseph Chen, Clayton, AU;
Monash University, Clayton, AU;
Mogrify Limited, Cambridge, GB;
National University of Singapore, Singapore, SG;
Abstract
A method for maintaining a cell in vitro that comprises the steps of: providing a cell of interest in cell culture, determining differential breadth of histone 3 trimethylated at lysine 4 (H3K4me3) modified regions and a differential broadness score for each protein-coding gene in said cell, determining a network score for each protein-coding gene in said cell based on the differential broadness score and interactions between the protein products of each protein-coding gene over at least one network, and determining a cell identity score for each protein-coding gene in said cell based on a combination of the differential broadness score and network scores. The cell identity scores are used to prioritise protein-coding genes thereby identifying cell identity genes for said cell, which encode factors associated with cell identity. The cell of interest is cultured in the presence of said factors, thereby maintaining the cell identity of the cell of interest.