The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 28, 2026

Filed:

Aug. 23, 2021
Applicant:

Nanyang Technological University, Singapore, SG;

Inventors:

Han Wei Hou, Singapore, SG;

Lingyan Gong, Singapore, SG;

Chayakorn Petchakup, Singapore, SG;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 15/1031 (2024.01); B01L 3/00 (2006.01); C12M 1/34 (2006.01); C12M 1/42 (2006.01); G01N 15/02 (2006.01); G01N 15/10 (2006.01); G01N 15/12 (2024.01); G01N 33/50 (2006.01); G01N 15/00 (2006.01);
U.S. Cl.
CPC ...
G01N 15/1031 (2013.01); B01L 3/502715 (2013.01); C12M 41/46 (2013.01); G01N 15/0266 (2013.01); G01N 15/1023 (2024.01); G01N 33/5011 (2013.01); B01L 2300/0645 (2013.01); B01L 2300/0816 (2013.01); G01N 2015/0092 (2013.01); G01N 2015/1029 (2024.01);
Abstract

A method of monitoring one or more cell aggregates, includes providing a flow path in which the one or more cell aggregates are in a medium and the flow path being configured to pass through a collective sensing zone of a set of electrodes, obtaining impedance-related signals corresponding to each of the medium and one of the one or more cell aggregates in the medium, and determining one or more electrical signatures for a cell aggregate, in which the one or more electrical signatures are based on impedance-related signals obtained from the set of electrodes. The method is one of dynamic testing at single-particle resolution. The electrical signatures may be an opacity and/or electrical size of the one or more cell aggregates, or electrical impedance spectroscopy-based electrical signatures. It is also to provide a microfluidic chip having a channel and electrodes for obtaining impedance-related signals.


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