The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 28, 2026
Filed:
Apr. 24, 2020
President and Fellows of Harvard College, Cambridge, MA (US);
Ohio State Innovation Foundation, Columbus, OH (US);
Massachusetts Eye and Ear Infirmary, Boston, MA (US);
David P. Corey, Cambridge, MA (US);
Artur Indzhykulian, Boston, MA (US);
Marcos Sotomayor, Columbus, OH (US);
Maryna V. Ivanchenko, Cambridge, MA (US);
Cole W. D. Peters, Cambridge, MA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
Ohio State Innovation Foundation, Columbus, OH (US);
Massachusetts Eye and Ear Infirmary, Boston, MA (US);
Abstract
Aspects of the disclosure relate to compositions, nucleic acids, vectors, viruses, and methods useful for treating hearing loss and/or blindness, for example, Usher Syndrome type IF. The present disclosure provides isolated nucleic acids, vectors, and rAAV.9.PHP.B comprising a transgene encoding a mini-PCDH15, and methods of treating hearing loss using the same. The present disclosure also provides a gRNA associated with a base editor to correct one or more mutations in PCDH15 for treating hearing loss and/or vision loss.