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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12612644 B1

PDFFull Text
Date of Patent:
Apr. 28, 2026

Filed:

Aug. 09, 2019

Scalable method for recombinant aav production

Applicant:

Regenxbio Inc., Rockville, MD (US);

Inventors:

Michael Gillmeister, Hanover, MD (US);

Miguel Valle, Potomac, MD (US);

Robert Stadelman, New Market, MD (US);

Franz Gerner, Myersville, MD (US);

Matthieu Guibert, Germantown, MD (US);

Bhargavi Kondragunta, Clarksburg, MD (US);

Assignee:

REGENXBIO INC., Rockville, MD (US);

Attorney:

Nixon & Vanderhye PC

Primary Examiner:

Anne Marie S Wehbe

Assistant Examiner:

Katie L Pennington

Int. Cl.
CPC ...
C12N 15/86 (2006.01); C07K 14/01 (2006.01); C07K 14/015 (2006.01); C12N 15/85 (2006.01); C12N 15/864 (2006.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); C07K 14/01 (2013.01); C07K 14/015 (2013.01); C12N 15/85 (2013.01); C12N 15/8645 (2013.01); C12N 2750/14151 (2013.01); C12N 2750/14152 (2013.01);
Abstract

Provided herein are improved methods for producing recombinant Adeno-Associated Virus (rAAV) particles. In some embodiments, a method for producing recombinant AAV (rAAV) particles provided herein comprises culturing cells capable of producing rAAV particles in the presence of a histone deacetylase (HDAC) inhibitor. In some embodiments, a method for producing recombinant AAV (rAAV) particles provided herein comprises culturing cells capable of producing rAAV particles in the presence of a histone deacetylase (HDAC) inhibitor and increased amount of a sodium salt.

Find Patent Forward Citations

Gillmeister, Michael. (2026). Scalable method for recombinant aav production (U.S. Patent No. 12612644). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12612644

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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