The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 28, 2026
Filed:
Mar. 04, 2025
Takeda Pharmaceutical Company Limited, Osaka, JP;
Kenichi Miyata, Fujisawa, JP;
Masahiro Nogami, Fujisawa, JP;
Akihiro Yokota, Fujisawa, JP;
Rumiko Ochiai, Fujisawa, JP;
Etsuko Shimobayashi, Fujisawa, JP;
Naoki Tomita, Fujisawa, JP;
Masato Niwa, Fujisawa, JP;
Zhaoma Shu, Fujisawa, JP;
Akiyoshi Kunugi, Fujisawa, JP;
Tatsuya Hayama, Fujisawa, JP;
Himari Yamazaki, Fujisawa, JP;
Takeda Pharmaceutical Company Limited, Osaka, JP;
Abstract
Antisense oligonucleotides for splicing modulation of UNC13A (e.g., inhibiting inclusion of an UNC13A cryptic exon into an UNC13A mature mRNA), compositions including the antisense oligonucleotides, and methods of use are described. Also disclosed are pharmaceutical compositions including one or more antisense oligonucleotides and methods of treating an UNC13A-associated disease or a disease associated with TDP-43 dysfunction in a subject by administering the antisense oligonucleotides to the subject.