The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 28, 2026
Filed:
Oct. 06, 2021
Vertex Pharmaceuticals Incorporated, Boston, MA (US);
Jason Mccartney, Cardiff by the Sea, CA (US);
Alexander Russell Abela, Escondido, CA (US);
Sunny Abraham, San Diego, CA (US);
Corey Don Anderson, Brighton, MA (US);
Vijayalaksmi Arumugam, San Marcos, CA (US);
Jaclyn Chau, San Diego, CA (US);
Jeremy Clemens, San Diego, CA (US);
Thomas Cleveland, San Marcos, CA (US);
Timothy A. Dwight, Quincy, MA (US);
Bryan A. Frieman, La Jolla, CA (US);
Peter Grootenhuis, Del Mar, CA (US);
Sara Sabina Hadida Ruah, La Jolla, CA (US);
Yoshihiro Ishihara, San Diego, CA (US);
Paul Krenitsky, San Francisco, CA (US);
Mark Thomas Miller, Rancho Santa Fe, CA (US);
Fabrice Pierre, La Jolla, CA (US);
Alina Silina, Needham, MA (US);
Jinglan Zhou, San Diego, CA (US);
Vertex Pharmaceuticals Incorporated, Boston, MA (US);
Abstract
This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having the core structure: pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, combination therapies, and processes and intermediates for making such modulators.