The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 28, 2026
Filed:
May. 20, 2021
Applicant:
Sironax Ltd., Grand Cayman, KY;
Inventors:
Yaning Su, Beijing, CN;
Zhiyuan Zhang, San Diego, CA (US);
Zhaolan Zhang, Beijing, CN;
Yanping Xu, Beijing, CN;
Assignee:
SIRONAX LTD., Grand Cayman, KY;
Primary Examiner:
Int. Cl.
CPC ...
C07D 403/12 (2006.01); A61P 39/00 (2006.01); C07D 401/14 (2006.01); C07D 403/14 (2006.01); C07D 491/107 (2006.01);
U.S. Cl.
CPC ...
C07D 403/12 (2013.01); A61P 39/00 (2018.01); C07D 401/14 (2013.01); C07D 403/14 (2013.01); C07D 491/107 (2013.01);
Abstract
The present disclosure provides compounds including piperazine heterocyclic amide urea compounds that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.