The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 28, 2026
Filed:
Nov. 29, 2022
Vertex Pharmaceuticals Incorporated, Boston, MA (US);
Leslie A. Dakin, Framingham, MA (US);
Michael A. Brodney, Newton, MA (US);
Kevin B. Daniel, Boston, MA (US);
Elena Dolgikh, Boston, MA (US);
Pedro M. Garcia Barrantes, Melrose, MA (US);
Ales Medek, Winchester, MA (US);
Jessica H. Olsen, Jamaica Plain, MA (US);
Timothy J. Senter, Arlington, MA (US);
Akira J. Shimizu, Framingham, MA (US);
Steven D. Stone, Quincy, MA (US);
Charlene Tsay, Boston, MA (US);
Vertex Pharmaceuticals Incorporated, Boston, MA (US);
Abstract
The disclosure provides at least one compound, tautomer, deuterated derivative, or pharmaceutically acceptable salt chosen from compounds of Formula I, tautomers thereof, deuterated derivatives of those compounds or tautomers, and pharmaceutically acceptable salts of any of the foregoing, compositions comprising the same, and methods of using the same, including uses in treating APOL1-mediated diseases, including pancreatic cancer, focal segmental glomerulosclerosis (FSGS), and/or non-diabetic kidney disease (NDKD).