The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 21, 2026
Filed:
Jun. 15, 2018
Applicant:
Sichuan Baili Pharmaceutical Co. Ltd., Chengdu, CN;
Inventors:
Yi Zhu, Chengdu, CN;
Yiqian Wang, Chengdu, CN;
Jie Li, Chengdu, CN;
Shi Zhuo, Chengdu, CN;
Weili Wan, Chengdu, CN;
Assignee:
SYSTIMMUNE, INC., Redmond, WA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 47/68 (2017.01); A61K 45/06 (2006.01); A61K 47/54 (2017.01); A61K 47/65 (2017.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6889 (2017.08); A61K 47/545 (2017.08); A61K 47/65 (2017.08); A61K 47/68031 (2023.08); A61K 47/6849 (2017.08); A61K 47/6851 (2017.08); A61K 45/06 (2013.01); A61P 35/00 (2018.01);
Abstract
The present invention provides a special drug conjugate having a hydrophilic acidic stabilization junction. Compared with a conjugate having a lower drug loading, due to the introduction of the acidic stabilization junction, the conjugate in the present invention can also have a higher drug loading (that is, each targeted reagent has more hydrophilic drug junctions), keeps a desired PK property and has a same or better activity in a body.