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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12605458 B1

PDFFull Text
Date of Patent:
Apr. 21, 2026

Filed:

Jun. 15, 2018

Antibody-drug conjugate having acidic self-stabilization junction

Applicant:

Sichuan Baili Pharmaceutical Co. Ltd., Chengdu, CN;

Inventors:

Yi Zhu, Chengdu, CN;

Yiqian Wang, Chengdu, CN;

Jie Li, Chengdu, CN;

Shi Zhuo, Chengdu, CN;

Weili Wan, Chengdu, CN;

Assignee:

SYSTIMMUNE, INC., Redmond, WA (US);

Attorney:

EpiMED LLC

Primary Examiner:

Julie Wu

Assistant Examiner:

Sydney Van Druff

Int. Cl.
CPC ...
A61K 47/68 (2017.01); A61K 45/06 (2006.01); A61K 47/54 (2017.01); A61K 47/65 (2017.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6889 (2017.08); A61K 47/545 (2017.08); A61K 47/65 (2017.08); A61K 47/68031 (2023.08); A61K 47/6849 (2017.08); A61K 47/6851 (2017.08); A61K 45/06 (2013.01); A61P 35/00 (2018.01);
Abstract

The present invention provides a special drug conjugate having a hydrophilic acidic stabilization junction. Compared with a conjugate having a lower drug loading, due to the introduction of the acidic stabilization junction, the conjugate in the present invention can also have a higher drug loading (that is, each targeted reagent has more hydrophilic drug junctions), keeps a desired PK property and has a same or better activity in a body.

Find Patent Forward Citations

Zhu, Yi. (2026). Antibody-drug conjugate having acidic self-stabilization junction (U.S. Patent No. 12605458). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12605458

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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