The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 21, 2026
Filed:
Nov. 15, 2020
Applicant:
Academia Sinica, Taipei City, TW;
Inventors:
Wen-Chin Yang, Taichung County, TW;
Keng-Chang Tsai, Taipei City, TW;
Assignee:
ACADEMIA SINICA, Taipei City, TW;
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/216 (2006.01); A61K 31/196 (2006.01); A61P 3/10 (2006.01);
U.S. Cl.
CPC ...
A61K 31/216 (2013.01); A61K 31/196 (2013.01); A61P 3/10 (2018.01);
Abstract
Disulfide-Isomerase A4 (PDIA4) inhibitors and use thereof for inhibiting pancreatic β-cell pathogenesis and treating diabetes are disclosed. Drug candidates that inhibit PDIA4 with IC50 values ranging from 4 μM to 300 nM are identified. The compounds are highly active in augmenting insulin secretion from pancreatic β-cells. The representative compound No. 8 (4,5-dimethoxy-2-propiolamidobenzoic acid), alone or in combination with metformin, is effective in preserving pancreatic β-cell function, treating and/or reversing, returning blood glucose concentration to a normal level in a diabetic.