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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12600971 B1

PDFFull Text
Date of Patent:
Apr. 14, 2026

Filed:

Feb. 13, 2020

Modified immune cells having adenosine deaminase base editors for modifying a nucleobase in a target sequence

Applicant:

Beam Therapeutics Inc., Cambridge, MA (US);

Inventors:

Nicole Gaudelli, Cambridge, MA (US);

Michael Packer, Cambridge, MA (US);

Ian Slaymaker, Cambridge, MA (US);

Yi Yu, Cambridge, MA (US);

Bernd Zetsche, Cambridge, MA (US);

David A. Born, Cambridge, MA (US);

Seung-Joo Lee, Cambridge, MA (US);

Jason M. Gehrke, Cambridge, MA (US);

Assignee:

BEAM THERAPEUTICS INC., Cambridge, MA (US);

Attorneys:

Greenberg Traurig, LLP

Melissa Hunter-Ensor

Nicholas R. Ballor

Primary Examiner:

Christopher M Babic

Assistant Examiner:

Jennifer S Spence

Int. Cl.
CPC ...
C12N 15/113 (2010.01); C12N 9/22 (2006.01); C12N 9/78 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1138 (2013.01); C12N 9/22 (2013.01); C12N 9/78 (2013.01); C12N 2310/20 (2017.05); C12N 2310/315 (2013.01); C12N 2310/346 (2013.01); C12N 2320/33 (2013.01); C12N 2510/00 (2013.01); C12Y 305/04004 (2013.01);
Abstract

The present invention features genetically modified immune cells comprising novel adenosine base editors (e.g., ABE8) having enhanced anti-neoplasia activity, resistance to immune suppression, and decreased risk of eliciting a graft-versus-host reaction or host-versus-graft reaction, or a combination thereof. The present invention also features methods for producing and using these modified immune effector cells.

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Quick Actions:

Gaudelli, Nicole. (2026). Modified immune cells having adenosine deaminase base editors for modifying a nucleobase in a target sequence (U.S. Patent No. 12600971). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12600971

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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