The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 14, 2026

Filed:

Mar. 19, 2025
Applicant:

Allife Medicine (Beijing) Limited, Beijing, CN;

Inventors:

Rulong Du, Beijing, CN;

Lei Yu, Beijing, CN;

Wenjing Huang, Beijing, CN;

Xuening Wu, Beijing, CN;

Yuchun Gu, Beijing, CN;

Lida Wu, Beijing, CN;

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/071 (2010.01); C07K 14/47 (2006.01); C12N 5/00 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0692 (2013.01); C07K 14/4702 (2013.01); C12N 5/0018 (2013.01); C12N 15/86 (2013.01); C12N 2501/115 (2013.01); C12N 2501/125 (2013.01); C12N 2501/145 (2013.01); C12N 2501/155 (2013.01); C12N 2501/165 (2013.01); C12N 2501/2303 (2013.01); C12N 2501/26 (2013.01); C12N 2501/999 (2013.01); C12N 2506/45 (2013.01); C12N 2750/14143 (2013.01);
Abstract

A method for preparing hematopoietic endothelial cells and a method for preparing hematopoietic stem cells are provided, comprising inducing hematopoietic mesodermal cells to express transcription factors LCOR, HOXA9, HOXA5, RUNX1, and ERG at specific time periods during the conversion of induced pluripotent stem cells into the hematopoietic endothelial cells or the hematopoietic stem cells. The method can increase the preparation efficiency of at least one of the hematopoietic endothelial cells and the hematopoietic stem cells (including long-term hematopoietic stem cells).


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