The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 14, 2026
Filed:
Jan. 31, 2020
Applicants:
The University of Hong Kong, Hong Kong, HK;
Children's Hospital Medical Center, Cincinnati, OH (US);
Inventors:
Sau-Wai Elly Ngan, Hong Kong, HK;
James M. Wells, Cincinnati, OH (US);
Assignees:
Children's Hospital Medical Center, Cincinnati, OH (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/0797 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0623 (2013.01); C12N 2500/32 (2013.01); C12N 2501/41 (2013.01); C12N 2501/999 (2013.01); C12N 2506/03 (2013.01);
Abstract
Disclosed are in vitro methods for the differentiation of precursor cells into a neural crest cell (NCC) primed to a neurogenic lineage. The methods may include, for example, the steps of activating a Hedgehog signaling pathway ('HH signaling pathway') in a precursor cell, wherein the precursor cell may be contacted with a neural crest cell induction medium for differentiation of the precursor cell into a neural crest cell. Compositions for carrying out the disclosed methods are also disclosed.