The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 14, 2026
Filed:
Apr. 30, 2021
The Charles Stark Draper Laboratory Inc., Cambridge, MA (US);
Jonathan R. Coppeta, Windham, NH (US);
Hesham Azizgolshani, Belmont, MA (US);
Brian P. Cain, Cambridge, MA (US);
Brett C. Isenberg, Newton, MA (US);
Joseph L. Charest, Jamaica Plain, MA (US);
Else M. Vedula, Stoneham, MA (US);
Ashley L. Gard, Dorchester, MA (US);
Ryan S. Maloney, Cambridge, MA (US);
Jeffrey T. Borenstein, West Roxbury, MA (US);
Rebeccah J. Luu, Cambridge, MA (US);
The Charles Stark Draper Laboratory, Inc., Cambridge, MA (US);
Abstract
The present disclosure describes systems and methods for providing culturing of a number of various tissue types in an air-liquid configuration in a high-throughput format and allowing co-culture of cells as well as application of physiologically relevant flow. A microfluidic cell culturing device is provided that includes a first channel having a first inlet port and a second inlet port, the first channel defined in a first layer. The microfluidic cell culturing device includes a membrane layer having a first surface coupled to the first layer defining the first channel, the membrane layer comprising semipermeable membrane that forms at least a portion of a surface of the first channel. The microfluidic cell culturing device includes a chamber defined in a second layer that exposes a portion the membrane layer to an external environment, wherein the chamber overlaps a portion of the first channel across the membrane layer.