The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 14, 2026

Filed:

Dec. 11, 2015
Applicant:

The Trustees of the University of Pennsylvania, Philadelphia, PA (US);

Inventor:

D. Kacy Cullen, Media, PA (US);

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/36 (2006.01); A61K 9/00 (2006.01); A61K 35/30 (2015.01); A61P 25/00 (2006.01); C12N 5/00 (2006.01); C12N 5/06 (2006.01); C12N 5/07 (2010.01); C12N 5/079 (2010.01); C12N 5/0793 (2010.01);
U.S. Cl.
CPC ...
A61K 47/36 (2013.01); A61K 9/0024 (2013.01); A61K 35/30 (2013.01); A61P 25/00 (2018.01); C12N 5/0068 (2013.01); C12N 5/06 (2013.01); C12N 5/0618 (2013.01); C12N 5/0619 (2013.01); C12N 5/0622 (2013.01);
Abstract

The invention includes a composition comprising an astrocyte comprising aligned and elongated astrocyte processes resulting from ex vivo machine-driven, physical stretching of the astrocyte maintained in culture, as well as a method of making it. The invention also includes a composition comprising an astrocyte comprising aligned bi-polar processes resulting from growth within hydrogel micro-columns in culture, as well as a method of making it. The invention also provides methods of treatment of nervous system injury or degeneration by implanting the compositions of the invention.


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