The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 14, 2026

Filed:

Aug. 20, 2019
Applicants:

The Regents of the University of California, Oakland, CA (US);

The J. David Giadstone Institutes, a Testamentary Trust Estabiished Under the Will of J. David, San Francisco, CA (US);

Inventors:

Christina Theodoris, San Francisco, CA (US);

Deepak Srivastava, San Francisco, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/55 (2006.01); A61K 31/132 (2006.01); A61K 31/198 (2006.01); A61K 31/396 (2006.01); A61K 31/426 (2006.01); A61K 31/433 (2006.01); A61K 31/44 (2006.01); A61K 31/485 (2006.01); A61K 31/506 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/55 (2013.01); A61K 31/132 (2013.01); A61K 31/198 (2013.01); A61K 31/396 (2013.01); A61K 31/426 (2013.01); A61K 31/433 (2013.01); A61K 31/44 (2013.01); A61K 31/485 (2013.01); A61K 31/506 (2013.01); A61K 45/06 (2013.01);
Abstract

The present disclosure provides methods of treating cardiac valve disease, e.g., calcific aortic valve disease (CAVD), by administering to a subject in need thereof a therapeutically effective amount of a compound of any one of Formulae I-X or a pharmaceutically acceptable salt, solvate or prodrug thereof. Also provided are methods of identifying a candidate compound for treatment of cardiac valve disease, e.g., CAVD.


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