The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 14, 2026

Filed:

Mar. 13, 2020
Applicants:

Board of Regents, the University of Texas System, Austin, TX (US);

Board of Trustees of the University of Arkansas, Little Rock, AR (US);

Inventors:

Zamal Ahmed, Houston, TX (US);

John A. Tainer, Houston, TX (US);

Darin E. Jones, Little Rock, AR (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/404 (2006.01); A61K 31/4184 (2006.01); A61K 31/423 (2006.01); A61K 31/5377 (2006.01); A61P 35/00 (2006.01); C07D 209/34 (2006.01); C07D 235/26 (2006.01); C07D 235/28 (2006.01); C07D 263/58 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01);
U.S. Cl.
CPC ...
A61K 31/404 (2013.01); A61K 31/4184 (2013.01); A61K 31/423 (2013.01); A61K 31/5377 (2013.01); A61P 35/00 (2018.01); C07D 209/34 (2013.01); C07D 235/26 (2013.01); C07D 235/28 (2013.01); C07D 263/58 (2013.01); C07D 405/12 (2013.01); C07D 409/12 (2013.01);
Abstract

The present disclosure compounds of the formula (I-A) or (I), wherein the variables are defined herein, as well as pharmaceutical compositions thereof. The present disclosure also provides methods for the use of said compounds and/or pharmaceutical compositions, such as in the treatment of cancer. The present disclosure also provides methods for the use of compounds of the formula (III), wherein the variables are defined herein.


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