The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 07, 2026
Filed:
Dec. 14, 2020
Merck Sharp & Dohme Llc, Rahway, NJ (US);
Michelle Machacek, Belmont, MA (US);
Michael D. Altman, Needham, MA (US);
Chunghui Huang, Arlington, MA (US);
Michael H. Reutershan, Brighton, MA (US);
David L. Sloman, Newton, MA (US);
Phieng Siliphaivanh, Newton Highlands, MA (US);
Sebastian E. Schneider, Cambridge, MA (US);
Charles S. Yeung, Dedham, MA (US);
David J. Witter, Toronto, CA;
Craig R. Gibeau, Northborough, MA (US);
Yingchun Ye, Belmont, MA (US);
Merck Sharp & Dohme LLC, Rahway, NJ (US);
Abstract
The present invention provides a compound of Formula (I) and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are PRMT5 inhibitors. Also provided are methods of making compounds of Formula I, pharmaceutical compositions comprising compounds of Formula I, and methods of using these compounds to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations.