The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 31, 2026
Filed:
Sep. 27, 2020
Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences, Beijing, CN;
Shuyi Si, Beijing, CN;
Yanni Xu, Beijing, CN;
Xiao Wang, Beijing, CN;
Jinque Luo, Beijing, CN;
Yongzhen Li, Beijing, CN;
Chao Liu, Beijing, CN;
Xinhai Jiang, Beijing, CN;
Yining Li, Beijing, CN;
Xiaowan Han, Beijing, CN;
Yan Li, Beijing, CN;
Minghua Chen, Beijing, CN;
Jing Zhang, Beijing, CN;
Xin Zhen, Beijing, CN;
Abstract
The disclosure relates to an indolo[2′,3′:3,4]pyrido[2,1-b]quinazoline compound represented by general formula (I) and use thereof in the manufacture of (1) a medicament for treating a cardiovascular and cerebrovascular disease, (2) a formulation for increasing expression of AMPK, ABCA1 and SR-BI, (3) a formulation for activating nuclear receptors (NRs), and inhibiting activity of NLRP3, IL-1β, NF-κB and MAPKs, (4) a formulation for promoting cellular cholesterol efflux; or (5) a medicament for anti-inflammation.