The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 24, 2026

Filed:

Aug. 09, 2019
Applicant:

The Scripps Research Institute, La Jolla, CA (US);

Inventors:

Chao Wang, San Diego, CA (US);

William E. Balch, San Diego, CA (US);

Assignee:

THE SCRIPPS RESEARCH INSTITUTE, La Jolla, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/6883 (2018.01); G16B 15/20 (2019.01); G16B 20/40 (2019.01); G16B 40/30 (2019.01); G16B 45/00 (2019.01);
U.S. Cl.
CPC ...
C12Q 1/6883 (2013.01); G16B 15/20 (2019.02); G16B 20/40 (2019.02); G16B 40/30 (2019.02); G16B 45/00 (2019.02); C12Q 2600/106 (2013.01); C12Q 2600/136 (2013.01); C12Q 2600/156 (2013.01);
Abstract

Drug administration is performed in view of variation spatial profiling (VSP) of patients or potential patients. Spatial-covariance (SCV) relationships relate the position of the disease-associated variant in the polypeptide chain with cell-based models and clinical features of disease. An understanding of SCV relationships for a sparse collection of known fiduciary variants can be used to generate the shape of phenotype landscapes that measure the differential disease behavior for unknown variants, and between distinct cell and tissue environments in patients. The phenotype landscapes can determine which pharmaceutical compounds are administered to potential patients.


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