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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12584098 B1

PDFFull Text
Date of Patent:
Mar. 24, 2026

Filed:

Feb. 06, 2019

In-vitro model of the human gut microbiome and uses thereof in the analysis of the impact of xenobiotics

Applicant:

European Molecular Biology Laboratory, Heidelberg, DE;

Inventors:

Melanie Tramontano, Heidelberg, DE;

Kiran Raosaheb Patil, Heidelberg, DE;

Martina Klünemann, Heidelberg, DE;

Mihaela Pruteanu, Berlin, DE;

Lisa Maier, Heidelberg, DE;

Michael Kuhn, Heidelberg, DE;

Sergej Andrejev, Heidelberg, DE;

Yongkyu Kim, Heidelberg, DE;

Peer Bork, Heidelberg, DE;

Athanasios Typas, Heidelberg, DE;

Georg Zeller, Heidelberg, DE;

Assignee:

EUROPEAN MOLECULAR BIOLOGY LABORATORY, Heidelberg, DE;

Attorney:

SALIWANCHIK, LLOYD & EISENSCHENK

Primary Examiner:

Robert J Yamasaki

Assistant Examiner:

Trevor undefined Kane

Int. Cl.
CPC ...
C12N 1/20 (2006.01); C12Q 1/02 (2006.01); C12Q 1/04 (2006.01);
U.S. Cl.
CPC ...
C12N 1/20 (2013.01); C12Q 1/025 (2013.01); C12Q 1/04 (2013.01);
Abstract

The present invention relates to an in-vitro model of the human gut microbiome, the model comprising a culture of the gut microbiome, wherein the model has a cumulative enzymatic coverage of more than 85% of the gut microbiome of a healthy human. The model facilitates metabolic modeling and enables a better understanding of the structure and function of the human gut microbiome as well as of modifications of xenobiotics by intrinsic gut microbiota, such as biotransformation and bioaccumulation. It can further be used to study the effects of variations in nutritional conditions. Importantly, the invention can also be used for diagnosing a disease, such as a gastrointestinal disorder, a proliferative disease, a metabolic disorder, a cardiovascular disease, an immunological disease, and an infectious disease.

Find Patent Forward Citations

Tramontano, Melanie. (2026). In-vitro model of the human gut microbiome and uses thereof in the analysis of the impact of xenobiotics (U.S. Patent No. 12584098). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12584098

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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