The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 24, 2026

Filed:

Sep. 25, 2020
Applicants:

Collaborations Pharmaceuticals, Inc., Raleigh, NC (US);

Universitätsklinikum Jena, Jena, DE;

Inventors:

Vadim Makarov, Moscow, RU;

Michaela Schmidtke, Jena, DE;

Sean Ekins, Fuquay Varina, NC (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 413/12 (2006.01); A61K 45/06 (2006.01); A61P 31/16 (2006.01);
U.S. Cl.
CPC ...
C07D 413/12 (2013.01); A61K 45/06 (2013.01); A61P 31/16 (2018.01);
Abstract

Isoxazole-3-carboxamide derivatives and their use in treating viral infections and diseases, such as diseases caused by viruses of the Picornaviridae family of viruses (e.g., rhinoviruses, enteroviruses, and coxsackieviruses) is described. The derivatives have good efficacy against a range of viruses, including pleconaril-resistant viral strains, and have low induction of cytochrome P4503A4 (CYP3A4).


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