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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12583822 B1

PDFFull Text
Date of Patent:
Mar. 24, 2026

Filed:

Jul. 28, 2021

Benzylamine derivative, preparation method therefor and use thereof

Applicant:

Academy of Military Medical Sciences, Beijing, CN;

Inventors:

Junhai Xiao, Beijing, CN;

Song Li, Beijing, CN;

Jialin Guo, Beijing, CN;

Wu Zhong, Beijing, CN;

Longlong Luo, Beijing, CN;

Zhibing Zheng, Beijing, CN;

Xinbo Zhou, Beijing, CN;

Xingzhou Li, Beijing, CN;

Ruiyuan Cao, Beijing, CN;

Shiyong Fan, Beijing, CN;

Dian Xiao, Beijing, CN;

Fei Xie, Beijing, CN;

Wei Li, Beijing, CN;

Assignee:

Academy of Military Medical Sciences, Beijing, CN;

Attorney:

Seed IP Law Group LLP

Primary Examiner:

Golam M Shameem

Int. Cl.
CPC ...
C07D 213/85 (2006.01); A61P 35/00 (2006.01); C07C 229/22 (2006.01); C07C 255/54 (2006.01); C07D 213/30 (2006.01); C07D 213/74 (2006.01); C07D 319/18 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01);
U.S. Cl.
CPC ...
C07D 213/85 (2013.01); A61P 35/00 (2018.01); C07C 229/22 (2013.01); C07C 255/54 (2013.01); C07D 213/30 (2013.01); C07D 213/74 (2013.01); C07D 319/18 (2013.01); C07D 401/12 (2013.01); C07D 405/12 (2013.01);
Abstract

The present invention relates to a benzylamine derivative, a preparation method therefor and use thereof, and in particular, to a benzylamine derivative as represented by general formula (I), or a pharmaceutically acceptable stereoisomer, salt, solvate or prodrug thereof, which has a strong binding capability with human PD-L1, can obviously inhibit the interaction of PD-1/PD-L1, and has significant anti-tumor efficacy in vivo. Therefore, the present invention also relates to a preparation method for the benzylamine derivative and use thereof in preparing a drug for treating PD-1/PD-L1-related diseases.

Find Patent Forward Citations

Xiao, Junhai. (2026). Benzylamine derivative, preparation method therefor and use thereof (U.S. Patent No. 12583822). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12583822

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