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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12583818 B1

PDFFull Text
Date of Patent:
Mar. 24, 2026

Filed:

Jan. 15, 2021

Compound, preparation method thereof, and use thereof

Applicants:

Daegu-gyeongbuk Medical Innovation Foundation, Daegu, KR;

Pimedbio, Inc., Gyeonggi-do, KR;

Inventors:

Chun Young Im, Daegu, KR;

Sang Hyun Min, Daegu, KR;

Ji Hoon Yu, Daegu, KR;

Eun Bi Ko, Daegu, KR;

So Young Kim, Daegu, KR;

Seungyeon Lee, Daegu, KR;

Dong Kyu Choi, Daegu, KR;

Heejin Lee, Daegu, KR;

Ga Young Park, Daegu, KR;

Doohyun Lee, Daegu, KR;

Eunmi Hong, Daegu, KR;

Hui-Jeon Jeon, Daegu, KR;

Young-Hoon Park, Daegu, KR;

Ye Ri Han, Daegu, KR;

Nam Hui Kim, Daegu, KR;

Jun Woo Kim, Daegu, KR;

Bae Jun Oh, Daegu, KR;

Jeong-Eun Park, Daegu, KR;

Chang Hoon Seo, Daegu, KR;

Minsoo Song, Daegu, KR;

Seonggu Ro, Gyeonggi-do, KR;

Dongkyu Shin, Gyeonggi-do, KR;

Assignees:

DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION, Daegu, KR;

PIMEDBIO, INC., Gyeonggi-do, KR;

Attorney:

Licata & Tyrrell P.C.

Primary Examiner:

Shawquia Jackson

Int. Cl.
CPC ...
C07D 209/14 (2006.01); C07C 311/29 (2006.01); C07D 207/27 (2006.01); C07D 209/16 (2006.01); C07D 209/86 (2006.01); C07D 211/10 (2006.01); C07D 235/06 (2006.01); C07D 235/14 (2006.01); C07D 295/12 (2006.01); C07D 295/14 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 403/12 (2006.01); C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
C07C 311/29 (2013.01); C07D 207/27 (2013.01); C07D 209/14 (2013.01); C07D 209/16 (2013.01); C07D 209/86 (2013.01); C07D 211/10 (2013.01); C07D 235/06 (2013.01); C07D 235/14 (2013.01); C07D 295/12 (2013.01); C07D 295/14 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 471/04 (2013.01);
Abstract

The present invention relates to a method for preparing a biomaterial having selectively functionalized tyrosine, a biomaterial having selectively functionalized tyrosine, and a pharmaceutical composition containing the same as an active ingredient. The method for preparing a biomaterial to which a compound represented by formula 2 is coupled, of the present invention, allows the compound represented by formula 2 to be selectively coupled, in a high yield in a biomaterial, to tyrosine, which is present on the surface of an aqueous solution such that the coupling thereof to amino acids other than tyrosine does not occur and, when only one tyrosine is present, heterogeneous mixtures are not present and the inherent activity of the biomaterial is maintained, and thus the compound can be effectively used as a pharmaceutical composition containing a biomaterial drug as an active ingredient. In addition, the method can selectively functionalize tyrosine, and thus can be effectively used for tyrosine functionalization in a biomaterial.

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