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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12583815 B1

PDFFull Text
Date of Patent:
Mar. 24, 2026

Filed:

Jul. 02, 2021

Inhibitors of yap/taz-tead oncoproteins, synthesis and use thereof

Applicant:

Bridgene Biosciences, Inc., San Jose, CA (US);

Inventors:

Chao Zhang, Monterey Park, CA (US);

Michael J. Bishop, San Diego, CA (US);

Hang Chen, San Jose, CA (US);

Ping Cao, San Jose, CA (US);

Assignee:

BRIDGENE BIOSCIENCES, INC., San Jose, CA (US);

Attorney:

Clark & Elbing LLP

Primary Examiner:

Kristin A Vajda

Int. Cl.
CPC ...
C07C 233/25 (2006.01); A61K 45/06 (2006.01); C07C 233/23 (2006.01); C07C 233/27 (2006.01); C07C 251/42 (2006.01); C07D 205/04 (2006.01); C07D 213/40 (2006.01); C07D 213/64 (2006.01); C07D 213/643 (2006.01); C07D 215/38 (2006.01); C07D 217/24 (2006.01); C07D 231/12 (2006.01); C07D 231/54 (2006.01); C07D 237/08 (2006.01); C07D 249/06 (2006.01); C07D 261/08 (2006.01); C07D 261/12 (2006.01); C07D 261/20 (2006.01); C07D 271/06 (2006.01); C07D 275/02 (2006.01); C07D 309/14 (2006.01); C07D 311/68 (2006.01); C07D 333/32 (2006.01); C07D 333/36 (2006.01);
U.S. Cl.
CPC ...
C07C 233/25 (2013.01); A61K 45/06 (2013.01); C07C 233/23 (2013.01); C07C 233/27 (2013.01); C07C 251/42 (2013.01); C07D 205/04 (2013.01); C07D 213/40 (2013.01); C07D 213/64 (2013.01); C07D 213/643 (2013.01); C07D 215/38 (2013.01); C07D 217/24 (2013.01); C07D 231/12 (2013.01); C07D 231/54 (2013.01); C07D 237/08 (2013.01); C07D 249/06 (2013.01); C07D 261/08 (2013.01); C07D 261/12 (2013.01); C07D 261/20 (2013.01); C07D 271/06 (2013.01); C07D 275/02 (2013.01); C07D 309/14 (2013.01); C07D 311/68 (2013.01); C07D 333/32 (2013.01); C07D 333/36 (2013.01); C07C 2602/08 (2017.05); C07C 2602/10 (2017.05); C07C 2602/50 (2017.05);
Abstract

Disclosed herein are synthesis and use of covalent inhibitors selective for Transcriptional Enhancer Factor TEF-1 (TEAD1), which can be used for treatment of cancers such as glioblastoma, gastric cancer, colorectal cancer, pancreatic ductal adenocarcinoma (PDAC), and malignant pleural mesothelioma (MPM). Further disclosed herein are pharmaceutical compositions including the TEAD1 inhibitor and methods of treating cancers using the same.

Find Patent Forward Citations

Zhang, Chao. (2026). Inhibitors of yap/taz-tead oncoproteins, synthesis and use thereof (U.S. Patent No. 12583815). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12583815

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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