The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 24, 2026

Filed:

Apr. 07, 2022
Applicant:

The Regents of the University of Michigan, Ann Arbor, MI (US);

Inventors:

Zhen Xu, Ann Arbor, MI (US);

Timothy Lewis Hall, Ann Arbor, MI (US);

Greyson Stocker, Ann Arbor, MI (US);

Man Zhang, Ann Arbor, MI (US);

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61N 7/00 (2006.01); A61B 8/00 (2006.01); A61B 8/12 (2006.01);
U.S. Cl.
CPC ...
A61N 7/00 (2013.01); A61B 8/12 (2013.01); A61B 8/4281 (2013.01); A61N 2007/0039 (2013.01); A61N 2007/0043 (2013.01);
Abstract

Minimally invasive histotripsy systems and methods are provided. In some embodiments, a minimally invasive histotripsy device is inserted into a patient. The device can be inserted endoscopically through a natural orifice of the patient, or laparoscopically through an incision in the patient's skin. The minimally invasive histotripsy device can be advanced to the target tissue and acoustically coupled to the target tissue before applying histotripsy therapy to the target tissue. In some embodiments, the minimally invasive histotripsy device includes a transducer array with a focal length of approximately 10-40 mm, a diameter of less than 35 mm, and the ability to create a peak negative focal pressure of at least 20 MPa.


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