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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12581252 B1

PDFFull Text
Date of Patent:
Mar. 17, 2026

Filed:

Apr. 29, 2021

Substituted pyrrolo[3,4-b]pyridines as pi3k-α inhibitors

Applicants:

Relay Therapeutics, Inc., Cambridge, MA (US);

D. E. Shaw Research, Llc, New York, NY (US);

Inventors:

Alessandro Boezio, Cambridge, MA (US);

Lucian V. Dipietro, Cambridge, MA (US);

Hakan Gunaydin, Cambridge, MA (US);

Thomas H. Mclean, Cambridge, MA (US);

Levi Charles Thomas Pierce, Cambridge, MA (US);

Fabrizio Giordanetto, New York, NY (US);

Yakov Pechersky, New York, NY (US);

Megan Bertrand-Laperle, Montreal, CA;

Alexandre Larivee, Montreal, CA;

Kashif Tanveer, Montreal, CA;

Michael Paul Deninno, Gales Ferry, CT (US);

Tarek Mohamed, Montreal, CA;

Assignees:

Relay Therapeutics, Inc., Cambridge, MA (US);

D. E. Shaw Research, LLC, New York, NY (US);

Attorneys:

Dechert LLP

John P. Rearick

Gang Wang

Primary Examiner:

Douglas M Willis

Int. Cl.
CPC ...
A61K 31/4035 (2006.01); A61B 5/00 (2006.01); A61K 31/404 (2006.01); A61K 31/4155 (2006.01); A61K 31/416 (2006.01); A61K 31/428 (2006.01); A61K 31/437 (2006.01); A61K 31/4375 (2006.01); A61K 31/4545 (2006.01); A61K 31/472 (2006.01); A61K 31/506 (2006.01); A61K 31/517 (2006.01); A61K 31/519 (2006.01); A61K 31/536 (2006.01); A61K 31/69 (2006.01); C07D 209/46 (2006.01); C07D 209/48 (2006.01); C07D 217/24 (2006.01); C07D 231/56 (2006.01); C07D 239/82 (2006.01); C07D 265/18 (2006.01); C07D 275/06 (2006.01); C07D 401/04 (2006.01); C07D 403/04 (2006.01); C07D 403/12 (2006.01); C07D 405/06 (2006.01); C07D 409/12 (2006.01); C07D 409/14 (2006.01); C07D 417/12 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 519/00 (2006.01); C07F 5/02 (2006.01); H04R 25/00 (2006.01);
U.S. Cl.
CPC ...
H04R 25/554 (2013.01); A61B 5/0026 (2013.01); A61B 5/746 (2013.01); A61K 31/4035 (2013.01); A61K 31/404 (2013.01); A61K 31/4155 (2013.01); A61K 31/416 (2013.01); A61K 31/428 (2013.01); A61K 31/437 (2013.01); A61K 31/4375 (2013.01); A61K 31/4545 (2013.01); A61K 31/472 (2013.01); A61K 31/506 (2013.01); A61K 31/517 (2013.01); A61K 31/519 (2013.01); A61K 31/536 (2013.01); A61K 31/69 (2013.01); C07D 209/46 (2013.01); C07D 209/48 (2013.01); C07D 217/24 (2013.01); C07D 231/56 (2013.01); C07D 239/82 (2013.01); C07D 265/18 (2013.01); C07D 275/06 (2013.01); C07D 401/04 (2013.01); C07D 403/04 (2013.01); C07D 403/12 (2013.01); C07D 405/06 (2013.01); C07D 409/12 (2013.01); C07D 409/14 (2013.01); C07D 417/12 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 519/00 (2013.01); C07F 5/025 (2013.01); H04R 2225/55 (2013.01);
Abstract

The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3Kα enzymes with the compounds and compositions of formula I-1. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3Kα signaling with the compounds and compositions of formula I-1.

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