The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 17, 2026
Filed:
Nov. 23, 2021
Case Western Reserve University, Cleveland, OH (US);
The United States Government As Represented BY the Department of Veteran Affairs, Washington, DC (US);
The Cleveland Clinic Foundation, Cleveland, OH (US);
Uh Cleveland Medical Center, Cleveland, OH (US);
Anant Madabhushi, Shaker Heights, OH (US);
Nathaniel Braman, Bethel Park, PA (US);
Siddharth Kunte, Toledo, OH (US);
Alberto Montero, Cleveland, OH (US);
Case Western Reserve University, Cleveland, OH (US);
The United States Government as Represented by The Department of Veteran Affairs, Washington, DC (US);
The Cleveland Clinic Foundation, Cleveland, OH (US);
UH Cleveland Medical Center, Cleveland, OH (US);
Abstract
The present disclosure relates to a method of determining a prognostic outlook for patients having metastatic breast cancer. The method includes receiving imaging data from an image of a patient that is receiving or that is to receive cycline dependent kinase 4 and 6 (CDK 4/6) inhibitor therapy for hormone receptor-positive (HR+) metastatic breast cancer. Radiomic heterogeneity features are extracted from imaging data associated with a metastasis within the imaging. A prognostic marker is determined from the radiomic heterogeneity features. The prognostic marker is indicative of a response of the patient to CDK 4/6 inhibitor therapy for HR+ metastatic breast cancer.