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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12577605 B1

PDFFull Text
Date of Patent:
Mar. 17, 2026

Filed:

May. 27, 2021

Printing droplets containing biological material

Applicant:

The Regents of the University of California, Oakland, CA (US);

Inventors:

Adam R. Abate, San Francisco, CA (US);

Linfeng Xu, San Francisco, CA (US);

Leqian Liu, San Francisco, CA (US);

Kai-Chun Chang, San Francisco, CA (US);

Assignee:

The Regents of the University of California, Oakland, CA (US);

Attorneys:

Edward J. Baba

Bozicevic, Field & Francis LLP

Primary Examiner:

Jennifer Wecker

Assistant Examiner:

Oyeleye Alexander Alabi

Int. Cl.
CPC ...
B01L 3/00 (2006.01); B01D 15/08 (2006.01); B01F 33/302 (2022.01); B01F 33/3033 (2022.01); B01J 20/285 (2006.01); B01J 20/287 (2006.01); B01J 20/32 (2006.01); B01L 7/00 (2006.01); B01L 9/00 (2006.01); B65G 47/80 (2006.01); B82Y 20/00 (2011.01); B82Y 30/00 (2011.01); B82Y 40/00 (2011.01); C12M 1/34 (2006.01); C12M 3/06 (2006.01); C12N 1/14 (2006.01); C12N 1/20 (2006.01); C12Q 1/02 (2006.01); C12Q 1/6806 (2018.01); C12Q 1/6827 (2018.01); C12Q 1/6844 (2018.01); C12Q 1/6848 (2018.01); C12Q 1/686 (2018.01); G01N 15/10 (2024.01); G01N 15/14 (2024.01); G01N 15/1433 (2024.01); G01N 21/29 (2006.01); G01N 21/33 (2006.01); G01N 21/64 (2006.01); G01N 21/65 (2006.01); G01N 21/76 (2006.01); G01N 30/02 (2006.01); G01N 30/60 (2006.01); G01N 30/72 (2006.01); G01N 33/00 (2006.01); G01N 33/50 (2006.01); G01N 33/543 (2006.01); G01N 33/557 (2006.01); G01N 33/574 (2006.01); G01N 33/58 (2006.01); G01N 33/68 (2006.01); G01N 35/00 (2006.01); H05B 45/10 (2020.01);
U.S. Cl.
CPC ...
C12Q 1/6806 (2013.01); B01L 3/502715 (2013.01); B01L 3/502784 (2013.01); C12Q 1/6827 (2013.01); C12Q 1/686 (2013.01); B01L 2200/027 (2013.01); B01L 2200/16 (2013.01); B01L 2300/0636 (2013.01); B01L 2300/0816 (2013.01); B01L 2300/0861 (2013.01); C12Q 2600/156 (2013.01);
Abstract

Provided is a method including encapsulating a biological material in a droplet having a volume of 500 nl or less, depositing the droplet to an addressable location of a substrate, and performing mass spectroscopy on the droplet. The method can further include conducting omic analysis on the droplet, such as sequencing DNA or analyzing mRNA, after the mass spectroscopy. In some cases, the method can be used to screen thousands of genetically different cells to identify correlations between genetics and the production of a metabolite, wherein the metabolite is detected by mass spectroscopy. Also provided is a system for performing the method.

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