The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 17, 2026
Filed:
Jun. 04, 2020
Vanderbilt University, Nashville, TN (US);
Taekyu Lee, Brentwood, TN (US);
Changho Han, Nashville, TN (US);
Jonathan J. Mills, Nashville, TN (US);
Kevin B. Teuscher, Nashville, TN (US);
Jianhua Tian, Montgomery, MD (US);
Kenneth M. Meyers, Nashville, TN (US);
Somenath Chowdhury, Nashville, TN (US);
Stephen W. Fesik, Nashville, TN (US);
Vanderbilt University, Nashville, TN (US);
Abstract
Quinazolin-4(3H)-one, 2,3-dihydroquinazolin-4(1H)-one, 3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one, and 3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione compounds and derivatives inhibit WDR5 and associated protein-protein interactions, and the compounds and their pharmaceutical compositions are useful for treating disorders and conditions in a subject, such as cancer cell proliferation.