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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12577219 B1

PDFFull Text
Date of Patent:
Mar. 17, 2026

Filed:

Nov. 10, 2021

Macrolide brefeldin a ester derivatives and use thereof

Applicant:

Ocean University of China, Qingdao, CN;

Inventors:

Changlun Shao, Qingdao, CN;

Yaoyao Jiang, Qingdao, CN;

Ming Liu, Qingdao, CN;

Changyun Wang, Qingdao, CN;

Meiyan Wei, Qingdao, CN;

Cuifang Wang, Qingdao, CN;

Assignee:

OCEAN UNIVERSITY OF CHINA, Qingdao, CN;

Attorney:

LEASON ELLIS LLP

Primary Examiner:

John S Kenyon

Assistant Examiner:

Sara Elizabeth Bell

Int. Cl.
CPC ...
C07D 313/00 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C07D 313/00 (2013.01); A61P 35/00 (2018.01);
Abstract

The ester derivatives of brefeldin A represented by Formula (I) in the inhibition of tumor proliferation. The compounds are prominent in the prevention or treatment of hyperproliferative diseases, including liver cancer, leukemia, breast cancer, colon adenocarcinoma, gastric cancer, lung cancer, Bart's esophageal cancer, cervical cancer, pancreatic cancer, endometrial cancer, bone cancer, lymphoma, kidney cancer, brain cancer, nerve cancer, nasopharyngeal cancer, oral cancer and colorectal cancer, and have the potential to be developed as antitumor agents.

Find Patent Forward Citations

Shao, Changlun. (2026). Macrolide brefeldin a ester derivatives and use thereof (U.S. Patent No. 12577219). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12577219

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