The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 17, 2026

Filed:

Oct. 25, 2021
Applicant:

Ningbo Combireg Pharmaceutical Technology Co., Ltd., Zhejiang, CN;

Inventors:

Gang Liu, Zhejiang, CN;

Yao MA, Zhejiang, CN;

Wenjun Yu, Zhejiang, CN;

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 243/14 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C07D 243/14 (2013.01); A61P 35/00 (2018.01); C07B 2200/05 (2013.01);
Abstract

Disclosed are a deuterated 1,4-benzodiazepine-2,5-dione compound and the use thereof. Provided is a compound as represented by formula I or a pharmaceutically acceptable salt thereof. The disclosed 1,4-benzodiazepine-2,5-dione active compound maintains the activity of inhibiting tumor cells and tumor stem cells, and prolongs the degradation function of in-vitro human liver microsomes on the compound, such that the half-life period is significantly prolonged, which provides a safer and more reliable candidate for developing new anti-tumor drugs.


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Liu, Gang. (2026). Deuterated 1,4-benzodiazepine-2,5-dione compound and use thereof (U.S. Patent No. 12577213). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12577213

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