The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 10, 2026
Filed:
Sep. 13, 2019
Applicant:
North Carolina State University, Raleigh, NC (US);
Inventors:
Michael Daniele, Raleigh, NC (US);
Ashlyn T. Young, Raleigh, NC (US);
Assignee:
NORTH CAROLINA STATE UNIVERSITY, Raleigh, NC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12M 3/00 (2006.01); B01L 3/00 (2006.01); C12M 1/12 (2006.01); C12M 3/06 (2006.01);
U.S. Cl.
CPC ...
C12M 23/16 (2013.01); C12M 21/08 (2013.01); C12M 25/14 (2013.01);
Abstract
Described herein are two-dimensional (2D) models of tissue barriers, methods of making and using the same, and on-model analysis techniques. Aspects of the present disclosure include systems and methods relating to microfluidic tissue models, in particular those of the vasculature-endothelial barrier. Systems and methods as described herein can utilize impedance mapping to assess model conditions in response to stimuli, for example the introduction of pharmaceutical compositions.