The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 10, 2026
Filed:
Mar. 25, 2024
Amgen Inc., Thousand Oaks, CA (US);
Ryan Paul Wurz, Newbury Park, CA (US);
Yunxiao Li, Thousand Oaks, CA (US);
Liping Pettus, Thousand Oaks, CA (US);
Brian Alan Lanman, Woodland Hills, CA (US);
Michael M. Yamano, Thousand Oaks, CA (US);
Wei Zhao, Westford, MA (US);
Benjamin Wigman, Woodland Hills, CA (US);
Adriano Bauer, Newbury Park, CA (US);
Andrew Smaligo, Thousand Oaks, CA (US);
Shon K. Booker, Sherman Oaks, CA (US);
John Stellwagen, Newbury Park, CA (US);
Abstract
The present disclosure provides compounds useful for the inhibition of KRAS G12D, G12V, G12A, G12S, G13D, Q61H, Q61L or G12C. The compounds have a general Formula I′: wherein the variables of Formula I' are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.