The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 03, 2026
Filed:
Mar. 02, 2022
Applicant:
Ndsu Research Foundation, Fargo, ND (US);
Inventors:
Dharmakeerthi Nawarathna, Fargo, ND (US);
Logeeshan Velmanickam, Fargo, ND (US);
Vidura Jayasooriya, Fargo, ND (US);
Assignee:
NDSU RESEARCH FOUNDATION, Fargo, ND (US);
Primary Examiner:
Int. Cl.
CPC ...
B01J 19/08 (2006.01); A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/42 (2025.01); C12M 1/00 (2006.01); C12M 1/42 (2006.01); C12N 5/0783 (2010.01); C12N 13/00 (2006.01);
U.S. Cl.
CPC ...
B01J 19/087 (2013.01); A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/4205 (2025.01); A61K 40/4211 (2025.01); C12M 23/34 (2013.01); C12M 35/02 (2013.01); C12N 5/0636 (2013.01); C12N 13/00 (2013.01); C12N 2501/515 (2013.01);
Abstract
The present invention relates to a device for a scalable biomanufacturing platform for the production of modified cells such as CAR-modified T-cells while eliminating on-target/off-tumor toxicity and decreasing the current production cost by 500 times (per treatment), and to attendant methods. The includes a first chamber for proliferating a population of cells and a second chamber for modifying the cells to express a desired T-cell receptor antigen.