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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12564631 B1

PDFFull Text
Date of Patent:
Mar. 03, 2026

Filed:

Jun. 18, 2021

Phytosphingosine derivatives as adjuvants in immune stimulation

Applicants:

Helmholtz-zentrum Für Infektionsforschung Gmbh, Braunschweig, DE;

Leibniz-institut Für Pflanzenbiochemie, Halle, DE;

Inventors:

Yanira Mendez-Gomez, Halle, DE;

Bernhard Westermann, Halle, DE;

Daniel Garcia-Rivera, Halle, DE;

Aldrin Vasco-Vidal, Halle, DE;

Ludger Wessjohann, Halle, DE;

Carlos A. Guzmán, Wolfenbüttel, DE;

Thomas Ebensen, Langenhagen, DE;

Kai Schulze, Wolfsburg, DE;

Peggy Riese, Braunschweig, DE;

Stephanie Trittel, Hannover, DE;

Assignees:

Helmholtz-Zentrum für Infektionsforschung GmbH, Braunschweig, DE;

Leibniz-Institut für Pflanzenbiochemie, Halle, DE;

Attorney:

Knobbe, Martens, Olson & Bear, LLP

Primary Examiner:

Bethany P Barham

Assistant Examiner:

Peter undefined Anthopolos

Int. Cl.
CPC ...
A61K 39/39 (2006.01); A61K 47/55 (2017.01); A61P 37/04 (2006.01); C07H 15/04 (2006.01); C07H 15/08 (2006.01); C07H 15/22 (2006.01); C07H 15/26 (2006.01);
U.S. Cl.
CPC ...
A61K 39/39 (2013.01); A61K 47/55 (2017.08); A61P 37/04 (2018.01); C07H 15/04 (2013.01); C07H 15/08 (2013.01); C07H 15/22 (2013.01);
Abstract

Phytosphingosine derivatives suitable as adjuvants in immune stimulation, pharmaceutical compositions comprising such compounds and the medical use of the compounds and/or compositions in therapeutic or prophylactic methods of immune stimulation in a subject, and for use in the treatment of a disease, for which stimulation of an immune response in a subject produces a therapeutic benefit. The phytosphingosine derivative may also be used as adjuvants in vaccinating a subject. The phytosphingosine derivative may also be used in stimulating antibody production, stimulating an immune response against infection, stimulating an immune response against a cancer, or preventing and/or treating septic shock. Methods for the manufacture of the derivatives comprising an Ugi-4-component reaction (Ugi-4CR) is also disclosed.

Find Patent Forward Citations

Mendez-Gomez, Yanira. (2026). Phytosphingosine derivatives as adjuvants in immune stimulation (U.S. Patent No. 12564631). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12564631

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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