The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 03, 2026
Filed:
Oct. 19, 2020
Applicant:
The Mclean Hospital Corporation, Belmont, MA (US);
Inventor:
Anju Vasudevan, Waltham, MA (US);
Assignee:
The McLean Hospital Corporation, Belmont, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 35/30 (2015.01); A61P 25/24 (2006.01); C12N 5/071 (2010.01);
U.S. Cl.
CPC ...
A61K 35/30 (2013.01); A61P 25/24 (2018.01); C12N 5/069 (2013.01); C12N 2501/115 (2013.01); C12N 2501/165 (2013.01); C12N 2501/415 (2013.01); C12N 2501/999 (2013.01); C12N 2506/02 (2013.01);
Abstract
Described herein are methods for generating human forebrain endothelial cells, compositions comprising the cells, and methods of use thereof in therapy. Provided herein are methods for generation of human embryonic forebrain-like endothelial cells (e.g., periventricular endothelial cells) from human embryonic stem cells; the methods include addition or GABA and WNT7A for efficient differentiation, and isolation of GABRB37CD31+ cell population by FACS.