The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 03, 2026
Filed:
Apr. 07, 2021
Applicant:
Syndax Pharmaceuticals, Inc., Waltham, MA (US);
Inventors:
Gerard M. Mcgeehan, Newtown Square, PA (US);
Peter Ordentlich, Lexington, MA (US);
Galit Rosen, Newton, MA (US);
Steven A. Smith, San Jose, CA (US);
Assignee:
Syndax Pharmaceuticals, Inc., New York, NY (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/506 (2006.01); A61K 31/496 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/506 (2013.01); A61K 31/496 (2013.01); A61P 35/00 (2018.01);
Abstract
The present invention is directed to combinations of menin inhibitors with one or more CYP3A4 inhibitors, pharmaceutical compositions thereof, and methods of treating cancer and other diseases mediated by the menin-HLL interaction. Accordingly, the present disclosure provides compounds, e.g., of Formula (II), which inhibit menin and are useful in the treatment of diseases mediated by the menin-MLL interaction in combination with a strong CYP3A4 inhibitor.