The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 03, 2026

Filed:

Apr. 09, 2021
Applicant:

Arizona Board of Regents on Behalf of the University of Arizona, Tucson, AZ (US);

Inventors:

Frank Porreca, Tucson, AZ (US);

Hisakatsu Ito, Tucson, AZ (US);

Edita Navratilova, Tucson, AZ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4709 (2006.01); A61K 31/40 (2006.01); A61K 31/485 (2006.01); A61P 25/04 (2006.01); A61P 25/20 (2006.01);
U.S. Cl.
CPC ...
A61K 31/485 (2013.01); A61K 31/40 (2013.01); A61K 31/4709 (2013.01); A61P 25/04 (2018.01); A61P 25/20 (2018.01);
Abstract

Chronic pain patients complain about sleep disturbance with a high probability, while sleep loss increases pain in chronic pain patients. Sleep problems and pain promote a vicious spiral, suggesting a need for simultaneous treatment of both. The present invention provides a method to treat pain-related sleep disorders through distribution of a therapeutic amount of a KOR antagonist. The use of KOR antagonist could be a novel therapeutic agent for sleep disturbance in chronic pain patients. Additionally, KOR antagonists could be used to improve sleep in other conditions, such as depression or general anxiety disorder, where KOR signaling is induced.


Find Patent Forward Citations

Porreca, Frank. (2026). Kappa opiod receptor antagonists for treating pain-related sleep disorders (U.S. Patent No. 12564586). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12564586

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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