The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 03, 2026
Filed:
Jul. 19, 2021
Applicant:
The General Hospital Corporation, Boston, MA (US);
Inventors:
Derin Sevenler, Cambridge, MA (US);
Rebecca Sandlin, Melrose, MA (US);
Mehmet Toner, Charlestown, MA (US);
Assignee:
The General Hospital Corporation, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01N 1/162 (2025.01); A01N 1/125 (2025.01); C12N 5/0783 (2010.01);
U.S. Cl.
CPC ...
A01N 1/162 (2025.01); A01N 1/125 (2025.01); C12N 5/0636 (2013.01); C12N 2533/74 (2013.01); C12N 2537/10 (2013.01);
Abstract
Hydrogel beads having tunable rates of loading and unloading of cryoprotective agents are provided herein. Such hydrogel beads can be dispersed throughout a cell suspension to enable loading and unloading of cryoprotective agents from cells in a gradual and distributed manner that protects the cells from osmotic damage. Lymphocyte viability after cryopreservation is significantly greater when cryoprotective agents are loaded and unloaded using hydrogel beads compared to conventional media exchange methods.