The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 24, 2026

Filed:

Nov. 16, 2017
Applicant:

Allele Biotechnology and Pharmaceuticals, Inc., San Diego, CA (US);

Inventors:

Jiwu Wang, La Jolla, CA (US);

Yuhui Ni, San Diego, CA (US);

Yuanyuan Zhao, San Diego, CA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/071 (2010.01); A61K 35/407 (2015.01); A61K 35/545 (2015.01); C12N 5/074 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0696 (2013.01); A61K 35/407 (2013.01); A61K 35/545 (2013.01); C12N 5/067 (2013.01); C12N 5/0672 (2013.01); C12N 2310/11 (2013.01); C12N 2501/60 (2013.01); C12N 2506/03 (2013.01); C12N 2506/45 (2013.01); C12N 2510/00 (2013.01);
Abstract

A novel method of inducing or producing hepatocytes from human induced pluripotent stem cells at an unprecedented efficiency and functionality. The core of the invention is the use of experimentally discovered mRNAs at multiple critical differentiation decision points along a pluripotent to mesendoderm to endoderm to hepatocytes pathway in a previously unknown manner.


Find Patent Forward Citations

Wang, Jiwu. (2026). Induction of hepatocytes by stem cell differentiation with rna (U.S. Patent No. 12559729). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12559729

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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