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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12559471 B1

PDFFull Text
Date of Patent:
Feb. 24, 2026

Filed:

Oct. 20, 2022

1,5-dihydro-2,4-benzodiazepine-3-one derivative and application thereof

Applicant:

Jiangsu Nhwa Pharmaceutical Co., Ltd, Jiangsu, CN;

Inventors:

Xiangqing Xu, Jiangsu, CN;

Yinli Qiu, Jiangsu, CN;

Qiang Guo, Jiangsu, CN;

Minquan Yu, Jiangsu, CN;

Song Zhao, Jiangsu, CN;

Quxiang Li, Jiangsu, CN;

Peng Jing, Jiangsu, CN;

Yuanyuan Hou, Jiangsu, CN;

Yingying Dong, Jiangsu, CN;

Guosheng Wu, Jiangsu, CN;

Shuang Zhang, Jiangsu, CN;

Aijun Lu, Jiangsu, CN;

Assignee:

JIANGSU NHWA PHARMACEUTICAL CO., LTD, Jiangsu, CN;

Attorneys:

NKL Law

Allen Xue

Primary Examiner:

Charanjit Aulakh

Int. Cl.
CPC ...
C07D 243/04 (2006.01); A61K 31/551 (2006.01); A61P 25/16 (2006.01); A61P 25/18 (2006.01); C07D 401/04 (2006.01); C07D 401/14 (2006.01); C07D 403/14 (2006.01); C07D 471/04 (2006.01); C07D 471/10 (2006.01);
U.S. Cl.
CPC ...
C07D 401/04 (2013.01); A61P 25/16 (2018.01); A61P 25/18 (2018.01); C07D 401/14 (2013.01); C07D 403/14 (2013.01); C07D 471/04 (2013.01); C07D 471/10 (2013.01);
Abstract

1,5-dihydro-2,4-benzodiazepine-3-one derivatives, such as a compound represented by formula I, acts on 5-HTand 5-HTreceptors. The selectivity for 5-HTis superior or similar to pimavanserin. The derivative is used for treating schizophrenia or Parkinson's disease, dementia-related behavioral disorders, and psychosis. The antipsychotic activity of the compound is equivalent to that of pimavanserin, the side effects of sedation and worsening of exercise are less than those of pimavanserin, and cardiotoxicity is less than that of pimavanserin.

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Xu, Xiangqing. (2026). 1,5-dihydro-2,4-benzodiazepine-3-one derivative and application thereof (U.S. Patent No. 12559471). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12559471

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