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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12558341 B1

PDFFull Text
Date of Patent:
Feb. 24, 2026

Filed:

Oct. 09, 2020

Oral complement factor d inhibitors

Applicant:

Biocryst Pharmaceuticals, Inc., Durham, NC (US);

Inventors:

Pravin L. Kotian, Hoover, AL (US);

Yarlagadda S. Babu, Birmingham, AL (US);

Weihe Zhang, Vestavia Hills, AL (US);

Peng-Cheng Lu, Vestavia Hills, AL (US);

Andrew E. Spaulding, Hoover, AL (US);

Wei Lv, Hoover, AL (US);

Zhao Dang, Vestavia Hills, AL (US);

Krishnan Raman, Birmingham, AL (US);

Assignee:

BioCryst Pharmaceuticals, Inc., Durham, NC (US);

Attorneys:

Foley Hoag LLP

Dana M. Gordon

Laura A. Wzorek

Primary Examiner:

Joseph K Mckane

Assistant Examiner:

Meghan C Heasley

Int. Cl.
CPC ...
A61K 31/343 (2006.01); A61K 31/381 (2006.01); A61K 31/404 (2006.01); A61K 31/4155 (2006.01); A61K 31/416 (2006.01); A61K 31/423 (2006.01); A61K 31/437 (2006.01); A61K 31/443 (2006.01); A61K 31/496 (2006.01); A61K 31/5377 (2006.01); C07D 209/42 (2006.01); C07D 231/56 (2006.01); C07D 261/20 (2006.01); C07D 275/04 (2006.01); C07D 307/81 (2006.01); C07D 333/58 (2006.01); C07D 405/04 (2006.01); C07D 405/06 (2006.01); C07D 407/12 (2006.01); C07D 471/04 (2006.01); C07D 493/04 (2006.01);
U.S. Cl.
CPC ...
A61K 31/343 (2013.01); A61K 31/381 (2013.01); A61K 31/404 (2013.01); A61K 31/4155 (2013.01); A61K 31/416 (2013.01); A61K 31/423 (2013.01); A61K 31/437 (2013.01); A61K 31/443 (2013.01); A61K 31/496 (2013.01); A61K 31/5377 (2013.01); C07D 209/42 (2013.01); C07D 231/56 (2013.01); C07D 261/20 (2013.01); C07D 275/04 (2013.01); C07D 307/81 (2013.01); C07D 333/58 (2013.01); C07D 405/04 (2013.01); C07D 405/06 (2013.01); C07D 407/12 (2013.01); C07D 471/04 (2013.01); C07D 493/04 (2013.01);
Abstract

Disclosed are compounds of formula (I), and pharmaceutically acceptable salts thereof, which are inhibitors of the complement system. Also provided are pharmaceutical compositions comprising such a compound, and methods of using the compounds and compositions in the treatment or prevention of a disease or condition characterized by aberrant complement system activity.

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