The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 17, 2026
Filed:
Jan. 23, 2023
Applicant:
Biocryst Pharmaceuticals, Inc., Durham, NC (US);
Inventors:
Pravin L. Kotian, Hoover, AL (US);
Zhao Dang, Vestavia Hills, AL (US);
Minwan Wu, Vestavia Hills, AL (US);
Assignee:
BioCryst Pharmaceuticals, Inc., Durham, NC (US);
Primary Examiner:
Int. Cl.
CPC ...
C07H 19/14 (2006.01); C07D 207/50 (2006.01); C07D 487/04 (2006.01); C07H 1/04 (2006.01);
U.S. Cl.
CPC ...
C07H 19/14 (2013.01); C07D 207/50 (2013.01); C07D 487/04 (2013.01); C07H 1/04 (2013.01);
Abstract
Provided are methods of making the active 5′-triphosphate form of galidesivir (compound 1) and the active 5′-triphosphate form of azasugar nucleoside analogues (compound 2): a potent anti-viral compound useful for broad spectrum treatment, suppression, and prevention of viral infections. The syntheses of compound 1 and compound 2 can be achieved via selective formation of protected intermediate 1b and protected intermediate 2b, respectively: